Below are some of the evidence-based practices for adults included in the U.S. Surgeon General's report and/or in the National Evidence-Based Practices Project and listed by Substance Abuse and Mental Health Services Association (SAMHSA) as practices proven to be effective for adults with serious mental illness.

• Illness Management and Recovery
• Family Psycho-education
• Assertive Community Treatment (ACT)
• Integrated Services for Adults with Co-occurring Mental Illness and Substance Abuse
• Medication Management (Algorithms)
• Supported Employment